Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling

  title={Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling},
  author={Mark R. Lundquist and Andrew J. Storaska and Ting-chun Liu and Scott D Larsen and Todd Evans and Richard R. Neubig and Samie R. Jaffrey},
The serum response factor (SRF) binds to coactivators, such as myocardin-related transcription factor-A (MRTF-A), and mediates gene transcription elicited by diverse signaling pathways. SRF/MRTF-A-dependent gene transcription is activated when nuclear MRTF-A levels increase, enabling the formation of transcriptionally active SRF/MRTF-A complexes. The level of nuclear MRTF-A is regulated by nuclear G-actin, which binds to MRTF-A and promotes its nuclear export. However, pathways that regulate… CONTINUE READING
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