Redistribution of voltage-gated sodium channels after nerve decompression contributes to relieve neuropathic pain in chronic constriction injury

@article{Tseng2014RedistributionOV,
  title={Redistribution of voltage-gated sodium channels after nerve decompression contributes to relieve neuropathic pain in chronic constriction injury},
  author={Thomas N. Tseng and Yu-Lin Hsieh and Michael L. Ko and Sung-Tsang Hsieh},
  journal={Brain Research},
  year={2014},
  volume={1589},
  pages={15-25}
}
Nerve decompression is an important therapeutic strategy to relieve neuropathic pain and promote the peripheral nerve regeneration. To address these issues, we investigated the effects of nerve decompression on relief of neuropathic pain behaviors, redistribution of voltage-gated sodium channels (VGSCs), and skin reinnervation with chronic constriction injury (CCI). At post-operative week (POW) 4, animals were divided into a decompression group, in which the ligatures were removed, and a CCI… CONTINUE READING
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