Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion.

@article{Brown1997RedistributionOV,
  title={Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion.},
  author={D Brown and R Lee and Joseph V. Bonventre},
  journal={The American journal of physiology},
  year={1997},
  volume={273 6 Pt 2},
  pages={F1003-12}
}
After ischemia and reperfusion, severe alterations in the cytoskeletal organization of renal tubular epithelial cells have been reported. These effects, accompanied by a modification in the polarized distribution of some membrane transport proteins, are especially evident in the proximal tubule. In normal proximal tubule cells, actin is concentrated in apical brush border microvilli, along with the actin-binding protein villin. Because villin plays an important role in actin bundling and in… CONTINUE READING