Redistribution of plasma membrane proteins by electroosmosis elicits cytosolic calcium response in tumor mast cells.

Abstract

Activation of mast cells and basophils by binding of ligands that crosslink and micro-aggregate cell surface receptors leads to a series of responses including a phosphoinositide cascade, elevation of intracellular free calcium ([Ca2+]i), morphological changes in the cell plasma membrane, and ultimately, exocytosis of granules containing histamine and other… (More)

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