Redistribution of plasma membrane proteins by electroosmosis elicits cytosolic calcium response in tumor mast cells.

@article{Feder1994RedistributionOP,
  title={Redistribution of plasma membrane proteins by electroosmosis elicits cytosolic calcium response in tumor mast cells.},
  author={Toni Feder and Watt W. Webb},
  journal={Journal of cellular physiology},
  year={1994},
  volume={161 2},
  pages={
          227-36
        }
}
Activation of mast cells and basophils by binding of ligands that crosslink and micro-aggregate cell surface receptors leads to a series of responses including a phosphoinositide cascade, elevation of intracellular free calcium ([Ca2+]i), morphological changes in the cell plasma membrane, and ultimately, exocytosis of granules containing histamine and other mediators of the allergic response. In rat basophilic leukemia (RBL) cells, a tumor mast cell line, stimulation by immunoglobulin E… CONTINUE READING
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