Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain.

@article{Gold2003RedistributionON,
  title={Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain.},
  author={Michael S Gold and Daniel Weinreich and Chang-Sook Kim and Ruizhong Wang and James J. S. Treanor and F rank Porreca and Josephine Lai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 1},
  pages={158-66}
}
The underlying mechanisms of neuropathic pain are poorly understood, and existing treatments are mostly ineffective. We recently demonstrated that antisense mediated "knock-down" of the sodium channel isoform, Na(V)1.8, reverses neuropathic pain behavior after L5/L6 spinal nerve ligation (SNL), implicating a critical functional role of Na(V)1.8 in the neuropathic state. Here we have investigated mechanisms through which Na(V)1.8 contributes to the expression of experimental neuropathic pain. Na… CONTINUE READING

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