Redistribution of LRIG proteins in psoriasis.

@article{Karlsson2008RedistributionOL,
  title={Redistribution of LRIG proteins in psoriasis.},
  author={Ter{\'e}se Karlsson and Elisabeth Bj{\"o}rntorp Mark and Roger Henriksson and H{\aa}kan Hedman},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 5},
  pages={
          1192-5
        }
}
The human leucine-rich repeats and immunoglobulin-like domains (LRIG) family is composed of three members, LRIG1, -2, and -3, which are all expressed in human skin. LRIG1 negatively regulates growth factor signaling and is involved in the regulation of epidermal stem cell quiescence. Ablation of Lrig1 in mice results in psoriasiform epidermal hyperplasia. Hence, the LRIG proteins may be important for epidermal homeostasis and in psoriasis. Therefore, we analyzed the LRIG mRNA levels and the… CONTINUE READING

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