Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia.

@article{Yamamoto2000RedistributionOB,
  title={Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia.},
  author={Cindy M Yamamoto and Amiya P Sinha Hikim and Phan Huynh and Benyamin Shapiro and Yanhe Lue and Wael A Salameh and Christina Wang and Ronald S. Swerdloff},
  journal={Biology of reproduction},
  year={2000},
  volume={63 6},
  pages={1683-90}
}
Programmed cell death occurs spontaneously during spermatogenesis and can be induced in a cell- and stage-specific manner by mild testicular hyperthermia. Studies using transgenic mice suggest the involvement of Bcl-2 proteins in regulating germ cell apoptosis. To delineate further the pathways involved, we examined the temporal changes in proapoptotic Bax and antiapoptotic Bcl-2 in rat testes after transient exposure to heat (43 degrees C for 15 min). Germ cell apoptosis, involving exclusively… CONTINUE READING