Redirection of tumor metastasis by expression of E-selectin in vivo

@article{Biancone1996RedirectionOT,
  title={Redirection of tumor metastasis by expression of E-selectin in vivo},
  author={Luigi Biancone and Masasuke Araki and Kimi Araki and Pierre Vassalli and Ivan Stamenkovic},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={581 - 587}
}
The selectin class of adhesion molecules plays a critical role in facilitating leukocyte adhesion to and subsequent transmigration of endothelium. On this basis, selectins have been suggested to promote tumor cell attachment to endothelium, thereby facilitating metastasis of certain types of tumors, although direct evidence for such a role is lacking. To explore this hypothesis, two sets of transgenic mice were developed: TgnES, which constitutively expresses cell surface E-selectin in all… CONTINUE READING

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