Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).

@article{Halteren2002RedirectionOH,
  title={Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).},
  author={Astrid G. S. van Halteren and Evelyne van Etten and Esther C. de Jong and R Bouillon and Bart O Roep and Chantal Mathieu},
  journal={Diabetes},
  year={2002},
  volume={51 7},
  pages={2119-25}
}
The active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), is a potent immunomodulator known to affect T-cells through targeting antigen-presenting cells such as dendritic cells (DCs). We studied the effects of a novel nonhypercalcemic 1,25(OH)(2)D(3) analog, TX527, on DC differentiation, maturation, and function with respect to stimulation of a committed human GAD65-specific autoreactive T-cell clone. Continuous addition of TX527 impaired interleukin (IL)-4 and… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2001
View 1 Excerpt

O’Garra A: 1 ,25-Dihydroxyvitamin D3 has a direct effect on naive CD4( ) T cells to enhance the development of Th2 cells

A Boonstra, FJ Barrat, C Crain, VL Heath, HF Savelkoul
J Immunol 167:4974–4980, • 2001
View 3 Excerpts

Regulatory T cells induced by 1 ,25-dihydroxyvitamin D(3) and mycophenolate mofetil treatment mediate transplantation

S Gregori, M Casorati, +3 authors L Adorini
tolerance. J Immunol 167:1945–1953, • 2001

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