Redirecting gene-modified T cells toward various cancer types using tagged antibodies.

@article{Tamada2012RedirectingGT,
  title={Redirecting gene-modified T cells toward various cancer types using tagged antibodies.},
  author={Koji Tamada and Degui Geng and Yukimi Sakoda and Navneeta Bansal and Ratika Srivastava and Zhaoyang Li and Eduardo Davila},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 23},
  pages={6436-45}
}
PURPOSE To develop an adaptable gene-based vector that will confer immune cell specificity to various cancer types. EXPERIMENTAL DESIGN Human and mouse T cells were genetically engineered to express a chimeric antigen receptor (CAR) that binds a fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR T cells. Various antibodies (Ab) currently in clinical use including cetuximab (Ctx), trastuzumab (Her2), and rituximab (Rtx) were conjugated with FITC and tested for their ability to… CONTINUE READING
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