Redirecting adenovirus to pulmonary endothelium by cationic liposomes

Abstract

Somatic gene transfer to the pulmonary endothelium may be a useful strategy for modifying the phenotype of endothelium and/or vascular smooth muscle in disorders such as primary pulmonary hypertension, ARDS or pulmonary metastatic disease. Adenoviral (Ad) vectors, although highly efficient in liver gene transfer, have proven to be limited for pulmonary gene… (More)
DOI: 10.1038/sj.gt.3301636

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