Redifferentiation of in vitro expanded adult articular chondrocytes by combining the hanging-drop cultivation method with hypoxic environment.

@article{Martinez2008RedifferentiationOI,
  title={Redifferentiation of in vitro expanded adult articular chondrocytes by combining the hanging-drop cultivation method with hypoxic environment.},
  author={I{\~n}igo Martinez and Jan Elvenes and Randi Olsen and Kjell Bertheussen and Oddmund Johansen},
  journal={Cell transplantation},
  year={2008},
  volume={17 8},
  pages={987-96}
}
The main purpose of this work has been to establish a new culturing technique to improve the chondrogenic commitment of isolated adult human chondrocytes, with the aim of being used during cell-based therapies or tissue engineering strategies. By using a rather novel technique to generate scaffold-free three-dimensional (3D) structures from in vitro expanded chondrocytes, we have explored the effects of different culture environments on cartilage formation. Three-dimensional chondrospheroids… CONTINUE READING

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