Redesigning enzymes by site-directed mutagenesis.

  title={Redesigning enzymes by site-directed mutagenesis.},
  author={A. R. Fersht and Goerge Winter},
  journal={Ciba Foundation symposium},
The systematic alteration of protein structure has now become possible with genetic engineering. Recent developments in techniques for the chemical synthesis of DNA fragments and in recombinant DNA technology have enabled the facile modification of proteins by highly specific mutagenesis of their genes. Enzymes with novel properties may be produced in large… CONTINUE READING