Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.

  title={Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.},
  author={Jordan R. Willis and Gopal Sapparapu and Sasha Murrell and Jean-Philippe Julien and Vidisha Singh and Hannah G King and Yan Xia and Jennifer A. Pickens and Celia C LaBranche and James C Slaughter and David C. Montefiori and Ian A. Wilson and Jens Meiler and James E. Crowe},
  journal={The Journal of clinical investigation},
  volume={125 6},
Several HIV envelope-targeting (Env-targeting) antibodies with broad and potent neutralizing activity have been identified and shown to have unusual features. Of these, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possesses unique structural elements that interact with protein and glycan features of the HIV Env glycoprotein. Here, we used the Rosetta software suite to design variants of the PG9 antibody HCDR3 loop with the goal of identifying variants… CONTINUE READING
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