Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.

Abstract

Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family. In contrast to all the other enzymes that are involved in the production of metabolites that elicit Ca2+ mobilization, SmNACE is virtually unable to transform NAD+ into the second messenger cyclic ADP-ribose (cADPR). Sequence alignments revealed that… (More)

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Cite this paper

@article{Kuhn2006RedesignOS, title={Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.}, author={Isabelle Kuhn and Esther Kellenberger and Didier Rognan and Frances E. Lund and H{\'e}l{\`e}ne Muller-Steffner and Francis Schuber}, journal={Biochemistry}, year={2006}, volume={45 39}, pages={11867-78} }