Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities.


The isochorismate and salicylate synthases are members of the MST family of enzymes. The isochorismate synthases establish an equilibrium for the conversion chorismate to isochorismate and the reverse reaction. The salicylate synthases convert chorismate to salicylate with an isochorismate intermediate; therefore, the salicylate synthases perform… (More)
DOI: 10.1016/


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