Redefinition of rubisco carboxylase reaction reveals origin of water for hydration and new roles for active-site residues.

@article{Kannappan2008RedefinitionOR,
  title={Redefinition of rubisco carboxylase reaction reveals origin of water for hydration and new roles for active-site residues.},
  author={Babu Kannappan and Jill E. Gready},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 45},
  pages={15063-80}
}
Crystallographic, mutagenesis, kinetic, and computational studies on Rubisco over three decades have revealed much about its catalytic mechanism and the role played by several active-site residues. However, key questions remain unanswered. Specific details of the carboxylase and oxygenase mechanisms, required to underpin the rational re-engineering of Rubisco, are still speculative. Here we address critical gaps in knowledge with a definitive comprehensive computational investigation of the… CONTINUE READING
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