Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects.

@article{Cefalu2009RedefiningTS,
  title={Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects.},
  author={William T. Cefalu and Robert J. Richards and L Yvonne Melendez-Ramirez},
  journal={Cleveland Clinic journal of medicine},
  year={2009},
  volume={76 Suppl 5},
  pages={S39-47}
}
Despite advances in diagnosis and treatment, type 2 diabetes mellitus (T2DM), overweight/obesity, cardiovascular disease, and their sequelae are major public health burdens worldwide. The understanding of the pathophysiology of T2DM has traditionally emphasized decreased insulin secretion and increased insulin resistance, but evolving concepts now include the role of incretin hormones in disease progression. A comprehensive approach to managing patients with T2DM requires targeting both the… CONTINUE READING