Redefining the origin and evolution of ovarian cancer: a hormonal connection.

  title={Redefining the origin and evolution of ovarian cancer: a hormonal connection.},
  author={Carlos Cardenas and Ayesha B. Alvero and Bo Seong Yun and Gil Mor},
  journal={Endocrine-related cancer},
  volume={23 9},
Ovarian cancer has the highest mortality of all female reproductive cancers. Late diagnosis, tumour heterogeneity and the development of chemoresistance contribute to this statistic and work against patient survival. Current studies have revealed novel concepts that impact our view on how ovarian cancer develops. The greatest impact is on our understanding that, as a disease, ovarian cancer has multiple cellular origins and that these malignant precursors are mostly derived from outside of the… 

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