Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases.

@article{Sakellariou2014RedefiningTM,
  title={Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases.},
  author={Giorgos Konstantinos Sakellariou and Malcolm J. Jackson and Aphrodite Vasilaki},
  journal={Free radical research},
  year={2014},
  volume={48 1},
  pages={12-29}
}
The production of reactive oxygen and nitrogen species (RONS) by skeletal muscle is important as it (i) underlies oxidative damage in many degenerative muscle pathologies and (ii) plays multiple regulatory roles by fulfilling important cellular functions. Superoxide and nitric oxide (NO) are the primary radical species produced by skeletal muscle and studies in the early 1980s demonstrated that their generation is augmented during contractile activity. Over the past 30 years considerable… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS