Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.

@article{Taguchi2014RedefiningTI,
  title={Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.},
  author={Atsuhiro Taguchi and Yusuke Kaku and Tomoko Ohmori and Sazia Sharmin and Minetaro Ogawa and Hiroshi Sasaki and Ryuichi Nishinakamura},
  journal={Cell stem cell},
  year={2014},
  volume={14 1},
  pages={53-67}
}
Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental origins of the metanephric mesenchyme (MM), which generates most kidney components. Unexpectedly, we find that posteriorly located T(+) MM precursors are developmentally distinct from Osr1(+) ureteric bud progenitors during the postgastrulation stage, and we identify phasic Wnt stimulation and stage-specific growth… CONTINUE READING
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