Redefining the DNA-Binding Domain of Human XPA

the DNA-Binding Domain of Human XPA},
  author={Norie Sugitani and Steven M. Shell and Sarah E. Soss and Walter J Chazin},
  booktitle={Journal of the American Chemical Society},
Xeroderma pigmentosum complementation group A (XPA) protein plays a critical role in the repair of DNA damage via the nucleotide excision repair (NER) pathway. XPA serves as a scaffold for NER, interacting with several other NER proteins as well as the DNA substrate. The critical importance of XPA is underscored by its association with the most severe clinical phenotypes of the genetic disorder Xeroderma pigmentosum. Many of these disease-associated mutations map to the XPA(98-219) DNA-binding… CONTINUE READING