Redefining oxidative stress.

  title={Redefining oxidative stress.},
  author={D. H. P. Jones},
  journal={Antioxidants & redox signaling},
  volume={8 9-10},
Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in humans becomes oxidized with age, in response to oxidative stress (chemotherapy, smoking), and in common diseases (type 2 diabetes, cardiovascular disease). However, data also show that redox of plasma GSH/GSSG is not equilibrated with the larger plasma cysteine/cystine (Cys/CySS) pool, indicating that the "balance" of… CONTINUE READING
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