Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.

@article{Oak2003RedWP,
  title={Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.},
  author={Min-Ho Oak and Marta Chataigneau and Therese M. Keravis and Thierry Chataigneau and Alain Beretz and Ramaroson Andriantsitohaina and J. -C. Stoclet and Soon-Jae Chang and Val{\'e}rie B. Schini-Kerth},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 6},
  pages={
          1001-7
        }
}
OBJECTIVE Moderate consumption of red wine has a beneficial effect on the cardiovascular system. This study examines whether red wine polyphenolic compounds (RWPCs) affect vascular endothelial growth factor (VEGF) expression, a major angiogenic and proatherosclerotic factor in vascular smooth muscle cells (VSMCs). METHODS AND RESULTS VEGF mRNA expression was assessed by Northern blot analysis and the release of VEGF by immunoassay in cultured VSMCs. Short-term and long-term exposure of VSMCs… CONTINUE READING

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