Red wine decreases cyclosporine bioavailability.

@article{Tsunoda2001RedWD,
  title={Red wine decreases cyclosporine bioavailability.},
  author={Shirley M Tsunoda and Robert Z. Harris and Uwe Christians and Ruben L. Velez and Richard B Freeman and Leslie Z. Benet and Andrew L Warshaw},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={70 5},
  pages={
          462-7
        }
}
BACKGROUND Many commonly ingested substances such as grapefruit juice and Hypericum perforatum (St John's wort) have been found to interact with important therapeutic agents such as cyclosporine (INN, ciclosporin). The mechanism for these interactions is thought to involve modulation of the activity of the drug-metabolizing enzyme cytochrome P4503A4 (CYP3A4) and/or the drug transport protein Pglycoprotein. In vitro data suggest that red wine may interact with CYP3A4 substrates such as… CONTINUE READING

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