Red flags for multiple system atrophy

@article{Kllensperger2008RedFF,
  title={Red flags for multiple system atrophy},
  author={M. K{\"o}llensperger and F. Geser and K. Seppi and M. Stampfer-Kountchev and M. Sawires and C. Scherfler and S. Boesch and Joerg Mueller and V. Koukouni and N. Quinn and M. T. Pellecchia and P. Barone and N. Schimke and R. Dodel and W. Oertel and E. Dupont and K. {\O}stergaard and C. Daniels and G. Deuschl and T. Gurevich and Nir Giladi and M. Coelho and C. Sampaio and C. Nilsson and H. Widner and F. Sorbo and A. Albanese and A. Cardozo and E. Tolosa and M. Abele and T. Klockgether and C. Kamm and T. Gasser and R. Djaldetti and C. Colosimo and G. Meco and A. Schrag and W. Poewe and G. Wenning},
  journal={Movement Disorders},
  year={2008},
  volume={23}
}
The clinical diagnosis of multiple system atrophy (MSA) is fraught with difficulty and there are no pathognomonic features to discriminate the parkinsonian variant (MSA-P) from Parkinson's disease (PD. [...] Key Method To study the diagnostic role of these features in MSA-P versus PD patients, a standardized red flag check list (RFCL) developed by the European MSA Study Group (EMSA-SG) was administered to 57 patients with probable MSA-P and 116 patients with probable PD diagnosed according to established…Expand
Red flags to spot the parkinsonian variant of multiple system atrophy
TLDR
A multicenter study performed by the European MSA Study Group that sought to determine whether certain clinical features could serve as 'red flags', or warning signs, to assist in the early diagnosis of MSA-P found that the identified red-flag categories may be useful as supportive criteria in diagnosing probable M SA-P. Expand
Red flags phenotyping: A systematic review on clinical features in atypical parkinsonian disorders.
TLDR
A systematic review to identify red flags and their clinical evidence in the differential diagnosis of common degenerative parkinsonism, including PD, MSA, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and dementia with Lewy body (DLB). Expand
Diagnosing multiple system atrophy at the prodromal stage
TLDR
Building on similar approaches as for PD and DLB, features on history-taking, clinical examination, and ancillary clinical testing that can predict the likelihood of an individual developing MSA are identified, while also distinguishing it from PD andDLB. Expand
Various Motor and Non-Motor Symptoms in Early Multiple System Atrophy
TLDR
Evaluating the frequency of various motor and non-motor symptoms including so-called “red flags” in patients with early MSA found that the diagnostic accuracy can be improved if these features are appropriately reflected in the new diagnostic criteria for MSA. Expand
Axial motor clues to identify atypical parkinsonism: A multicentre European cohort study.
TLDR
This study suggests that simple "bedside" PIGD tests - particularly the combination of tandem gait performance, TUG and retropulsion test - can discriminate APD from PD. Expand
Diagnosis of multiple system atrophy
TLDR
Despite advances in the diagnostic tools for MSA in recent years and the availability of consensus criteria for clinical diagnosis, the diagnostic accuracy of MSA remains sub-optimal. Expand
Multiple System Atrophy: Clinical Features and Management
Publisher Summary This chapter summarizes the clinical features of multiple system atrophy (MSA), emphasizing useful clinical differential diagnostic clues versus Parkinson's disease (PD), andExpand
Eye signs in patients with parkinsonism: do they predict the development of multiple system atrophy?
  • W. Fletcher
  • Medicine
  • Nature Clinical Practice Neurology
  • 2008
TLDR
Several issues to consider before adopting oculomotor signs as predictors of MSA are outlined, including the study's high proportion of patients with late-stage MSA, its use of data from previous studies without matching for patient or study variables, the confounding effect of combining data from parkinsonian and cerebellar variants of M SA, conflicting data reported in previous studies, and the effect of disease prevalence on the positive predictive value of such signs. Expand
[Multiple system atrophy].
TLDR
No specific therapy is available for cerebellar dysfunction, while effective treatments exist for urinary and cardiovascular autonomic failure, and physical therapy may help to improve the difficulties of gait and stance, and to prevent their complications. Expand
Improving diagnostic accuracy of multiple system atrophy: a clinicopathological study.
TLDR
Increased likelihood of multiple system atrophy versus Lewy body disease and progressive supranuclear palsy if a patient developed orthostatic hypotension or urinary incontinence with the requirement for urinary catheters and autonomic dysfunction within the first 3 years from onset is revealed. Expand
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