Red cell exchange: special focus on sickle cell disease.

  title={Red cell exchange: special focus on sickle cell disease.},
  author={H. Charles Kim},
  journal={Hematology. American Society of Hematology. Education Program},
  volume={2014 1},
The primary function of red blood cells (RBCs) is to deliver oxygen from the lungs to tissues. Tissue hypoxia occurs when the oxygen-carrying capacity of RBCs is compromised due primarily to 3 causes: (1) a reduction in circulating RBC mass, (2) an increase in circulating RBC mass, or (3) abnormal hemoglobin (Hb) that either does not sufficiently release oxygen to tissues (high-oxygen-affinity hemoglobin) or occludes the microvasculature due to deformed RBCs (sickled RBCs). To improve… CONTINUE READING
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