Red blood cells express a functional endothelial nitric oxide synthase.

  title={Red blood cells express a functional endothelial nitric oxide synthase.},
  author={Petra Kleinbongard and Rainer Schulz and Tienush Rassaf and Thomas W Lauer and Andr{\'e} Dejam and Thomas Walter Jax and Intan Fatah Kumara and Putrika Prastuti Ratna Gharini and Svetlana A. Kabanova and Burcin Oz{\"u}yaman and H. G. Schn{\"u}rch and Axel G{\"o}decke and Artur Aron Weber and Mirko J. Robenek and Horst Robenek and Wilhelm Bloch and Peter R{\"o}sen and Malte Kelm},
  volume={107 7},
The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a nonfunctional NO synthase (NOS) and, due to their huge hemoglobin content, have been assumed to metabolize large quantities of NO. More recently, however, RBCs have been identified to reversibly bind, transport, and release NO within the cardiovascular system. We now provide evidence that RBCs from humans express an active… 

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