Red blood cell transfusion is a determinant of neurological complications after cardiac surgery.

@article{Mariscalco2015RedBC,
  title={Red blood cell transfusion is a determinant of neurological complications after cardiac surgery.},
  author={Giovanni Mariscalco and Fausto Biancari and Tatu Sakari Juvonen and Marco Zanobini and Marzia Cottini and Maciej Banach and Gavin James Murphy and Cesare Beghi and Gianni Davide Angelini},
  journal={Interactive cardiovascular and thoracic surgery},
  year={2015},
  volume={20 2},
  pages={
          166-71
        }
}
OBJECTIVES The aim of this study was to evaluate the impact of red blood cell (RBC) transfusions on the occurrence of stroke and transient ischaemic attack (TIA) after cardiac surgery. METHODS Data on 14 956 patients undergoing coronary artery bypass grafting (CABG) and valve surgery (with or without concomitant CABG) were retrieved at three European University Hospitals. The prognostic impact of RBC transfusion on postoperative stroke and TIA was investigated by logistic regression and… 
View on PubMed
academic.oup.com
28 Citations
Background Citations
4
Methods Citations
1
Results Citations
1

28 Citations

Citation Type

Citation Type

The impact of minor blood transfusion on the outcome after coronary artery bypass grafting
Bleeding, transfusion and the risk of stroke after coronary surgery: A prospective cohort study of 2357 patients.
Effect of Blood Product Transfusion on Perioperative Outcomes After Heart Transplantation.
TLDR
Intra- and postoperative transfusions (first 24 hours) of RBC and FFP were associated with adverse postoperative composite outcomes in patients undergoing OHT.
Use of Blood Products and Diseased Ascending Aorta Are Determinants of Stroke After Off-Pump Coronary Artery Bypass Grafting.
TLDR
The results of this study indicated that atherosclerosis of the ascending aorta as well as transfusion of platelets and/or Octaplas were independent predictors of stroke after OPCAB.
Impact of transfusion on stroke after cardiovascular interventions: Meta‐analysis of comparative studies☆
After Off-Pump Coronar Use of Blood Products and Diseased Ascending Aorta Are Determinants of Stroke y Artery Bypass Grafting
TLDR
The effect of blood products on the occurrence of stroke after coronary artery surgery and the number of transfused blood products as well as the timing, type, and course of stroke were examined.
A model-based cost-effectiveness analysis of Patient Blood Management.
TLDR
The results indicate that PBM may be associated with fewer adverse clinical outcomes compared to control management and may, thereby, be cost-effective.
Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery
TLDR
In the cardiac surgery setting, the use of PCC compared with FFP was associated with decreased post-operative blood loss and RBC transfusion requirements, however, PCC administration may be associated with a higher risk of post-operatively AKI.
Measurement of total hemoglobin reduces red cell transfusion in hospitalized patients undergoing cardiac surgery: a retrospective database analysis
Introduction: Historically, perioperative hemoglobin monitoring has relied on calculated saturation, using blood gas devices that measure plasma hematocrit (Hct). Co-oximetry, which measures total…
Red blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery.
TLDR
Red blood cell transfusion induces blunting of postoperative Hif-1 α response and is associated with higher risk of adverse thrombotic and pulmonary adverse events after cardiac surgery and greater decrease in HIF-1α levels predicted worse in-hospital and 3mo adverse outcome.
...
1
2
3
...

References

SHOWING 1-10 OF 38 REFERENCES
Use of blood products and risk of stroke after coronary artery bypass surgery.
TLDR
Transfusion of blood products after CABG has a strong, dose-dependent association with the risk of stroke, and the use of Octaplas and platelet transfusions seem to have an even larger impact on the development of stroke than red blood cell transfusions.
Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality.
Intraoperative hemoglobin levels and transfusion independently predict stroke after cardiac operations.
Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting*
TLDR
Perioperative red blood cell transfusion is the single factor most reliably associated with increased risk of postoperative morbid events after isolated coronary artery bypass grafting.
The independent effects of anemia and transfusion on mortality after coronary artery bypass.
Association between venous thromboembolism and perioperative allogeneic transfusion.
TLDR
In this large observational study of patients undergoing colorectal cancer resection, perioperative allogeneic blood transfusion was associated with an increased risk of venous thromboembolism in women but not in men.
Blood transfusion: the epidemic continues.
  • B. Bidstrup
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2012
TLDR
There is an increasing body of evidence relating to adverse effects of transfusion impacting on short-and long-term outcomes after cardiac surgery, and this has also been reported in critically ill patients, those with acute coronary syndrome and trauma patients.
Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery.
Preoperative statin therapy is not associated with a decrease in the incidence of delirium after cardiac operations.
Duration of red-cell storage and complications after cardiac surgery.
TLDR
In patients undergoing cardiac surgery, transfusion of red cells that had been stored for more than 2 weeks was associated with a significantly increased risk of postoperative complications as well as reduced short-term and long-term survival.
...
1
2
3
4
...