Red blood cell nitric oxide as an endocrine vasoregulator: a potential role in congestive heart failure.

@article{Datta2004RedBC,
  title={Red blood cell nitric oxide as an endocrine vasoregulator: a potential role in congestive heart failure.},
  author={Borunendra N Datta and Timothy Tufnell-Barrett and Robert A. Bleasdale and Christopher J. H. Jones and Ian Beeton and Vincent De Paul and Michael P. Frenneaux and Philip James},
  journal={Circulation},
  year={2004},
  volume={109 11},
  pages={1339-42}
}
BACKGROUND A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF). METHODS AND RESULTS We investigated the capacity for red blood cells (RBCs) to dilate preconstricted aortic rings under various O2 tensions. RBCs induced cyclic guanylyl… CONTINUE READING