Red blood cell lactate transport in sickle disease and sickle cell trait.

@article{Pattillo2005RedBC,
  title={Red blood cell lactate transport in sickle disease and sickle cell trait.},
  author={Robin E. Pattillo and L. Bruce Gladden},
  journal={Journal of applied physiology},
  year={2005},
  volume={99 3},
  pages={
          822-7
        }
}
This study determined and compared rates and mechanisms of lactate transport in red blood cells (RBCs) of persons with 1) sickle cell disease (HbSS), 2) sickle cell trait (HbAS), and 3) a control group (HbAA). Blood samples were drawn from 30 African-American volunteers (10 HbSS, 10 HbAS, 10 HbAA). Lactate influx into RBCs was measured by using [14C]lactate at six (2, 5, 10, 15, 25, and 40 mM) unlabeled lactate concentrations. The monocarboxylate transporter pathway was blocked by p… 
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Faster lactate transport across red blood cell membrane in sickle cell trait carriers.
TLDR
Although AS and AA had the same maximal aerobic physical fitness, the RBCs from the sickle cell trait carriers took up more lactate at low and high concentrations than the R BCs from AA individuals, which suggests greater content or greater activity of MCT-1 in AS RBC membranes.
Faster lactate transport across red blood cell membrane in sickle cell trait carriers
TLDR
Although AS and AA had the same maximal aerobic physical fitness, the RBCs from the sickle cell trait carriers took up more lactate at low and high concentrations than the R BCs from AA individuals, which suggests greater content or greater activity of MCT-1 in AS RBC membranes.
Altered plasma hexose sugar metabolism in sickle cell anaemia
TLDR
Theoretical suggestion that the metabolism and plasma levels of some hexoses (glucose and fructose) in sickle cell anaemia could be altered was investigated and the differences between the ‘Glucose-to-Fructose Ratio’ for the different states are very significant and could serve as biomarker of sickle Cell anaemia intensity.
Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?
TLDR
It is demonstrated that greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of M CT-1 in hemorheological disturbances in SCT carriers.
membrane in sickle cell trait carriers Faster lactate transport across red blood cell
TLDR
This article cites 31 articles, 9 of which you can access free at: http://jap.physiology.org/cgi/content/full/100/2/427#BIBL Updated information and services including high-resolution figures, can be found at: www.the-aps.org.
Warming-Up Affects Performance and Lactate Distribution between Plasma and Red Blood Cells.
TLDR
It seems that the influx into RBC decreases with increasing intracellular lactate concentrations, and warm-up and maximal effort exercise affects the lactate distribution between plasma and RBC.
Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease
TLDR
The SCD group exhibited higher mean values of heart rate during exercise than those observed in the SCT and normal control children, and SCD children showed higher serum lactate values before and after treadmill exercise compared to the other groups.
Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions.
Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters
  • I. Simpson, A. Carruthers, S. Vannucci
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2007
TLDR
Simulations based on concentrations and kinetic parameters of GLUT1 and −3 in BBB endothelial cells, astrocytes, and neurons, along with the corresponding kinetic properties of the MCTs, have successfully modeled brain glucose and lactate levels as well as lactate transients in response to neuronal stimulation.
Capturing Intracellular pH Dynamics by Coupling Its Molecular Mechanisms within a Fully Tractable Mathematical Model
TLDR
The construction of a fully tractable mathematical model based on coupling the kinetic equations depicting the molecular mechanisms for pumps, transporters and chemical reactions, which determine this parameter in eukaryotic cells is described.
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