Red blood cell carbonic anhydrase mediates oxygen delivery via the Root effect in red drum

@article{Dichiera2020RedBC,
  title={Red blood cell carbonic anhydrase mediates oxygen delivery via the Root effect in red drum},
  author={Angelina M. Dichiera and A. Esbaugh},
  journal={Journal of Experimental Biology},
  year={2020},
  volume={223}
}
ABSTRACT Oxygen (O2) and carbon dioxide (CO2) transport are tightly coupled in many fishes as a result of the presence of Root effect hemoglobins (Hb), whereby reduced pH reduces O2 binding even at high O2 tensions. Red blood cell carbonic anhydrase (RBC CA) activity limits the rate of intracellular acidification, yet its role in O2 delivery has been downplayed. We developed an in vitro assay to manipulate RBC CA activity while measuring Hb-O2 offloading following a physiologically relevant CO2… Expand
1 Citations
Contrasting strategies of hypoxic cardiac performance and metabolism in cichlids and armoured catfish.

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