Red Cell Membrane Lipid Peroxidation and Hemolysis Secondary to Phototherapy

@article{Ostrea1985RedCM,
  title={Red Cell Membrane Lipid Peroxidation and Hemolysis Secondary to Phototherapy},
  author={Enrique M. Ostrea and Eugene E. Cepeda and C A Fleury and James E Balun},
  journal={Acta P{\ae}diatrica},
  year={1985},
  volume={74}
}
ABSTRACT. The exposure of red cells to phototherapy light in the presence of a sensitizer (bilirubin) resulted in oxidative injury to the red cell membrane as manifested by a significant increase in the concentration of the products of lipid peroxidation (TBA reactants and diene conjugation) in the membrane and hemolysis. To induce a photo‐oxidized membrane injury, the sensitizer (bilirubin) has to be membrane bound. Thus, by altering the availability of free bilirubin in the red cell… 
Oxidative stress, phototherapy and the neonate
TLDR
Although intensive phototherapy (up to 40 mwatt/cm2/nm) has been reported to be increasingly effective, a little caution is warranted, till more definite data in the human neonate, help resolve the issue.
Antioxidant defense systems in newborns undergoing phototherapy
TLDR
The results of the in vivo study do not confirm the thesis that phototherapy is an oxidative stress in newborn infants undergoing phototherapy, and phototherapy would preferably seem to be safe and efficient method of treatment for all neonates presenting with hyperbilirubinemia.
Antioxidant status in neonatal jaundice before and after phototherapy
TLDR
It was observed that levels of MDA were elevated significantly in patients as compared to controls and that the levels increased significantly after phototherapy, and the plasma albumin levels also were found to be decreased significantly afterPhototherapy, which increases oxidative stress and should be used with care.
Phototherapy and Photo-Oxidation in Premature Neonates
TLDR
Overall, short term phototherapy in premature infants was effective in reducing TPB concentrations without associated evidence reflective of photo-oxidation.
Photooxidant injury to glucose‐6‐phosphate dehydrogenase‐deficient erythrocytes with bilirubin as the sensitizer—an in vitro study
TLDR
Antioxidant drugs may have a protective role while G6PD‐deficient neonates undergo phototherapy.
Phototherapy in the newborn: what's new?
TLDR
In conclusion, phototherapy is not a treatment without side effects and overtreatment should be reevaluated in small preterm infants and there is no superiority in clinical settings.
Oxidants -Antioxidant Status in Neonatal Jaundic With Severe G6PD Deficiency
TLDR
Data indicates an increases in free radical generation and thus antioxidant defense mechanisms is impaired in peroxidation associated with a significant elevation in MDA levels in the erythrocytes of neonatal jaundice with severe G6PD deficiency than that found in the control group which demonstrate the presence of an increased oxidative stress due to reduction in NADPH which is generated in RBCs by HMPshunt only.
Evaluation of oxidant and antioxidant status in term neonates: a plausible protective role of bilirubin
TLDR
The present study propounds that bilirubin acts as a physiological antioxidant till 200 mg/l concentration in full-term normal neonates, and conjectured that beyond 200  mg/l, it can no longer be considered physiologic.
Phototherapy Increases Hemoglobin Degradation and Bilirubin Production in Preterm Infants
TLDR
Phototherapy increases hemoglobin degradation and bilirubin production in preterm infants, and ETCOc was measured in pre term infants before and during phototherapy.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Erythropoietic protoporphyria: lipid peroxidation and red cell membrane damage associated with photohemolysis.
TLDR
In the present report, lipid peroxidation during in vitro irradiation of EPP red cells with long ultraviolet light was demonstrated by the formation of 2-thiobarbituric acid reactants and the presence of conjugated diene bonds in red cell lipid, providing further evidence suggesting that the cell membrane is a primary site of the photohemolytic effect of longraviolet light in EPPred cells.
The Autoxidation of Human Red Cell Lipids Induced by Hydrogen Peroxide
TLDR
Lack of reproducibility, a feature of previous methods of measuring the susceptibility of red cells to exogenous peroxide, could be overcome by (i) catalase inhibition, (ii) attention to the non‐linear relation between packed‐cell volume and MDA formation, and (iii) elimination of potentially misleading coloured complexes on spectroscopy.
The Haemolytic Action of Dapsone: Changes in the Red‐Cell Membrane
TLDR
Dapsone caused abnormal peroxide lysis in the presence of normal hydrogen peroxide detoxification mechanisms and in the absence of vitamin E deficiency, and it was increased by previous treatment with p‐chloromercuribenzoate.
The effect of calcium on phospholipid peroxidation.
  • J. Gutteridge
  • Chemistry, Biology
    Biochemical and biophysical research communications
  • 1977
Hemolysis by diphenylsulfones: comparative effects of DDS and hydroxylamine-DDS.
TLDR
Results indicated that this chemical derivative of DDS may be responsible for some of the known side-effects of this antimalarial and antileprosy drug.
The lack of effects of phototherapy on neonatal oxygen dissociation curves and hemoglobin concentration in vivo.
TLDR
It is suggested that phototherapy in vivo neither affectsfetal erythrocytic affinity for oxygen nor causes hemolysis, and the magnitude of changes in P50, 2,3-DPG, and hemoglobin concentration was similar in the phototherapy and control groups and was related to the expected changes with reference to postnatal age.
Bilirubin binding by human erythrocytes.
  • D. Bratlid
  • Medicine, Biology
    Scandinavian journal of clinical and laboratory investigation
  • 1972
TLDR
Determination of erythrocyte-bound bilirubin may be of clinical significance in cases of neonatal jaundice and is mainly dependent on the molar bilirUBin/albumin ratio.
Effect of light on fetal red blood cells in vivo.
Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process.
TLDR
The net effect of these events represents the operation of repair processes which distort the usual fatty acid composition of erythrocyte membranes in the presence of H(2)O(2).
...
1
2
3
4
...