Recycling probability and dynamical properties of germinal center reactions.

@article{MeyerHermann2001RecyclingPA,
  title={Recycling probability and dynamical properties of germinal center reactions.},
  author={Michael Meyer-Hermann and A. Deutsch and Michal Or-Guil},
  journal={Journal of theoretical biology},
  year={2001},
  volume={210 3},
  pages={265-85}
}
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Mathematical modeling of lymphocytes selection in the germinal center.

Journal of mathematical biology • 2017
View 16 Excerpts
Highly Influenced

Trade-offs in antibody repertoires to complex antigens

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2015

References

Publications referenced by this paper.
Showing 1-10 of 52 references

The germinal center: a crucible for lymphocyte selection.

Seminars in immunology • 1996
View 6 Excerpts
Highly Influenced

Germinal Centers without T Cells

The Journal of experimental medicine • 2000
View 1 Excerpt

A mathematical model on germinal center kinetics and termination

C. KESMIR, R. J. DE BOER
J. Immunol • 1999

Similar Papers

Loading similar papers…