Recycling probability and dynamical properties of germinal center reactions.

  title={Recycling probability and dynamical properties of germinal center reactions.},
  author={Michael Meyer-Hermann and A. Deutsch and Michal Or-Guil},
  journal={Journal of theoretical biology},
  volume={210 3},
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 52 references

The germinal center: a crucible for lymphocyte selection.

Seminars in immunology • 1996
View 6 Excerpts
Highly Influenced

Germinal Centers without T Cells

The Journal of experimental medicine • 2000
View 1 Excerpt

A mathematical model on germinal center kinetics and termination

J. Immunol • 1999

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