Recycling of vitamin E in human low density lipoproteins.

  title={Recycling of vitamin E in human low density lipoproteins.},
  author={Valerian E Kagan and Elena A Serbinova and Trudy Forte and G Scita and Lester Packer},
  journal={Journal of lipid research},
  volume={33 3},
Oxidative modification of low density lipoproteins (LDL) and their unrestricted scavenger receptor-dependent uptake is believed to account for cholesterol deposition in macrophage-derived foam cells. It has been suggested that vitamin E that is transported by LDL plays a critical role in protecting against LDL oxidation. We hypothesize that the maintenance of sufficiently high vitamin E concentrations in LDL can be achieved by reducing its chromanoxyl radicals, i.e., by vitamin E recycling. In… CONTINUE READING


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