Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain.

@article{Gao2010RecyclingOT,
  title={Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain.},
  author={Yajuan Gao and Corina M. Balut and Mark A. Bailey and Genaro Pati{\~n}o-L{\'o}pez and Stephen Shaw and Daniel C Devor},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 23},
  pages={17938-53}
}
Regulation of the number of Ca(2+)-activated K(+) channels at the endothelial cell surface contributes to control of the endothelium-derived hyperpolarizing factor response, although this process is poorly understood. To address the fate of plasma membrane-localized KCa2.3, we utilized an extracellular epitope-tagged channel in combination with fluorescence and biotinylation techniques in both human embryonic kidney cells and the human microvascular endothelial cell line, HMEC-1. KCa2.3 was… CONTINUE READING
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