Recycling of a glycosylphosphatidylinositol-anchored heparan sulphate proteoglycan (glypican) in skin fibroblasts.

@article{Fransson1995RecyclingOA,
  title={Recycling of a glycosylphosphatidylinositol-anchored heparan sulphate proteoglycan (glypican) in skin fibroblasts.},
  author={L A Fransson and Gudrun Edgren and Birgitta Havsmark and Artur Schmidtchen},
  journal={Glycobiology},
  year={1995},
  volume={5 4},
  pages={407-15}
}
We have used suramin and brefeldin A to investigate the nature of a heparan sulphate proteoglycan that appears to recycle from the cell surface to intracellular compartments which synthesize new heparan sulphate chains. Suramin, which would block internalization and deglycanation of a putative recycling cell surface proteoglycan, markedly increases the yield of a membrane-bound proteoglycan with a core protein of 60-70 kDa and unusually long heparan sulphate side chains. When transport of newly… CONTINUE READING

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