Recycling of Apolipoprotein(a) After PlgRKT-Mediated Endocytosis of Lipoprotein(a).

@article{Sharma2017RecyclingOA,
  title={Recycling of Apolipoprotein(a) After PlgRKT-Mediated Endocytosis of Lipoprotein(a).},
  author={Monika Sharma and Gregory M. I. Redpath and Michael J A Williams and Sally P. A. McCormick},
  journal={Circulation research},
  year={2017},
  volume={120 7},
  pages={1091-1102}
}
RATIONALE Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like lipoprotein and important cardiovascular risk factor whose cognate receptor and intracellular fate remains unknown. OBJECTIVE Our study aimed to determine the intracellular trafficking pathway for Lp(a) and the receptor responsible for its uptake in liver cells. METHODS AND RESULTS Human hepatoma cells were treated with Lp(a) purified from human plasma and Lp(a) uptake studied using Western blot analysis and intracellular… CONTINUE READING