Recycling glycoproteins do not return to the cis-Golgi

  title={Recycling glycoproteins do not return to the cis-Golgi},
  author={Jacques Neefjes and J M Verkerk and Henricus J. Broxterman and Gijs A. van Der Marel and Jacques H. van Boom and Hidde L. Ploegh},
  journal={The Journal of Cell Biology},
  pages={79 - 87}
Recycling of a number of glycoproteins along the site of action of mannosidase I (the distal endoplasmic reticulum/cis-Golgi) was followed in several different cell lines. Treatment of cells with 1-deoxymannojirimycin (dMM) produced high mannose oligosaccharides at positions otherwise occupied by complex-type oligosaccharides in these glycoproteins. Conversion of high-mannose-type oligosaccharides to complex oligosaccharides of proteins initially synthesized in the presence of dMM was used as a… CONTINUE READING


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