Recycling class I MHC antigens: dynamics of internalization, acidification, and ligand-degradation in murine T lymphoblasts.

@article{Tse1986RecyclingCI,
  title={Recycling class I MHC antigens: dynamics of internalization, acidification, and ligand-degradation in murine T lymphoblasts.},
  author={Doris B. Tse and Charles R. Cantor and Joanne McDowell and Benvenuto Pernis},
  journal={The Journal of molecular and cellular immunology : JMCI},
  year={1986},
  volume={2 6},
  pages={315-29}
}
We have previously shown that activated T lymphocytes spontaneously internalize their own surface class I MHC antigens and that this phenomenon is specific for these cells since it does not occur in B lymphocytes even after activation. The present work was aimed at defining the quantitative aspects of this phenomenon and, in particular, at the elucidation of the route of the internalized class I MHC antigens. We intended to determine if the internalized molecules are delivered to the lysosomal… CONTINUE READING