Recycled synaptic vesicles contain vesicle but not plasma membrane marker, newly synthesized acetylcholine, and a sample of extracellular medium.

Abstract

To monitor the fate of the synaptic vesicle membrane compartment, synaptic vesicles were isolated under varying experimental conditions from blocks of perfused Torpedo electric organ. In accordance with previous results, after low-frequency stimulation (0.1 Hz, 1,800 pulses) of perfused blocks of electric organ, a population of vesicles (VP2 type) can be… (More)

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