Recycled addition of CD4+ T cell-rich population for induction of human autologous cytotoxic T lymphocytes: A practically efficient method

@article{Saijo2000RecycledAO,
  title={Recycled addition of CD4+ T cell-rich population for induction of human autologous cytotoxic T lymphocytes: A practically efficient method},
  author={Kaoru Saijo and Hideo Tsurushima and Kouji Tsuboi and Tadao Nose and Akinori Oki and Tetsuo Ohno},
  journal={Cytotechnology},
  year={2000},
  volume={34},
  pages={101-110}
}
When CD4+ T cell-rich population appears in theinitial trial in induction cultures of humanautologous cytotoxic T lymphocytes (CTL), the cultureresults frequently in no or weak killing activity andtherefore usually be discarded as an `unsuccessful'CTL induction culture. However, addition of theinitial CD4+ T cell-rich population enabledefficient induction of the autologous CTL in theensuing trials. The CTL thus generated exhibitedstronger killing activities against autologous braintumor cells… CONTINUE READING

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