Recursive splicing in long vertebrate genes

  title={Recursive splicing in long vertebrate genes},
  author={Christopher R. Sibley and Warren Emmett and Lorea Blazquez and Ana Faro and Nejc Haberman and Michael Briese and Daniah Trabzuni and Mina Ryten and Michael E. Weale and John Hardy and Miha Modic and Toma{\vz} Curk and Stephen W. Wilson and Vincent Plagnol and Ule Jernej},
It is generally believed that splicing removes introns as single units from precursor messenger RNA transcripts. However, some long Drosophila melanogaster introns contain a cryptic site, known as a recursive splice site (RS-site), that enables a multi-step process of intron removal termed recursive splicing. The extent to which recursive splicing occurs in other species and its mechanistic basis have not been examined. Here we identify highly conserved RS-sites in genes expressed in the… CONTINUE READING
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