Recurring views on the structure and function of the cytoskeleton: a 300-year epic.

@article{Frixione2000RecurringVO,
  title={Recurring views on the structure and function of the cytoskeleton: a 300-year epic.},
  author={Eugenio Frixione},
  journal={Cell motility and the cytoskeleton},
  year={2000},
  volume={46 2},
  pages={
          73-94
        }
}
  • E. Frixione
  • Published 1 June 2000
  • Medicine, Biology
  • Cell motility and the cytoskeleton
Some unnoticed or seldom remembered precedents of current views on biological motion and its structural bases are briefly outlined, followed by a concise recapitulation of how the present theory has been constructed in the last few decades. It is shown that the evolution of the concept of fibers as main constituents of living matter led to hypothesizing microscopic structures closely resembling microtubules in the 18th century. At the beginning of this period, fibers sliding over each other and… Expand
Sigmund Freud's Contribution to the History of the Neuronal Cytoskeleton
  • E. Frixione
  • Psychology, Medicine
  • Journal of the history of the neurosciences
  • 2003
TLDR
Sigmund Freud was able to discern separate fine fibrils following straight courses within the nerve fibers, as well as concentric loops of striae surrounding the nuclei and converging towards the processes of the cell bodies in crayfish nervous tissue. Expand
The Cytoskeleton of Nerve Cells in Historic Perspective
Neurons can be usually distinguished at once from most other cells by their peculiar multibranched shapes, which allow them to maximize their spatial reach and surface-to-volume ratios while keepingExpand
Muscle microanatomy and its changes during contraction: the legacy of William Bowman (1816–1892)
  • E. Frixione
  • Biology, Medicine
  • Journal of Muscle Research & Cell Motility
  • 2005
TLDR
It is shown that not only Bowman succeeded in establishing the true architecture of striated muscle fibres to the extent possible with the most advanced technology available in his day but also in correctly describing the basic microstructural changes associated with contraction. Expand
Computational and Modeling Strategies for Cell Motility
A predictive simulation of the dynamics of a living cell remains a fundamental modeling and computational challenge. The challenge does not even make sense unless one specifies the level of detailExpand
Structural Organization of Cells – The Cytoskeleton
TLDR
The cytoskeleton has become the focus of increasing attention for biomedical research, as its direct etiological role in various diseases, or its potential as a target for alternative therapeutic action in other health disorders, is being explored. Expand
Cajal's second great battle for the neuron doctrine: the nature and function of neurofibrils
  • E. Frixione
  • Psychology, Medicine
  • Brain Research Reviews
  • 2009
TLDR
His comprehensive reply, published in 1908, meant the effective end of the renewed reticularist campaign against the neuron doctrine and a visionary and today almost forgotten chapter in the history of the cytoskeleton was written. Expand
MDI: integrity index of cytoskeletal fibers observed by AFM
Abstract.The Modified Directional Index (MDI) is a form factor of the angular spectrum computed from the 2D Fourier transform of an image marking the prevalence of rectilinear features throughout theExpand
Neura, nerves, nerve fibers, neurofibrils, microtubules: multidimensional routes of pain, pleasure, and voluntary action in images across the ages.
  • E. Frixione
  • Psychology, Medicine
  • Progress in brain research
  • 2013
TLDR
All the progressive stages in understanding nerve construction, at increasingly more detailed scales, have been accompanied by technological advances and by debate about the structure and function relationship. Expand
The prehistory of the cytoskeleton concept
Here we discuss how the concept and the name of cytoskeleton were generated and started to evolve over the last two centuries into what is presently a basic topic of modern biology. We also attemptExpand
Active biological materials.
TLDR
Results indicate that a complex interplay between length scales and timescales underlies the mechanical responses of these systems and that energy consumption, as manifested in molecular motor activity and cytoskeletal filament growth, can drive transitions between distinct material states. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 406 REFERENCES
RETICULAR ORGANIZATIONS WITHIN THE STRIATED MUSCLE CELL
  • D. S. Smith
  • Biology, Medicine
  • The Journal of biophysical and biochemical cytology
  • 1961
TLDR
It is shown that workers in the early years of this century by no means ignored or abandoned the unfinished lines of approach inherited from the last, and at the turn of the century there was scarcely a single aspect of muscle organization that was not entirely controversial. Expand
MICROTUBULE RESEARCH JN PERSPECTIVE
The subject of this conference may have a short history but it has a long memory. Microtubule research began long before microtubules were discovered; many of the questions we are asking were askedExpand
A personal view of muscle and motility mechanisms.
  • H. Huxley
  • Biology, Medicine
  • Annual review of physiology
  • 1996
TLDR
How synchrotron radiation has made it possible to obtain detailed structural information about contracting muscle with millisecond time resolution is described and some of the recent major advances in the field are discussed and the prospects of reaching a full understanding of the contraction mechanism are discussed. Expand
A MOVING IMAGE OF FLAGELLA: NEWS AND VIEWS ON THE MECHANISMS INVOLVED IN AXONEMAL BEATING
  • J. Cosson
  • Biology, Medicine
  • Cell biology international
  • 1996
TLDR
The present study puts forward ideas as to how these organelles have been highly conserved throughout eucaryotic evolution, and concludes with suggestions for further fields of investigation into this unique mechanical device used for cell movement. Expand
THE ULTRASTRUCTURE OF FLAGELLAR FIBRILS
  • D. Pease
  • Biology, Medicine
  • The Journal of cell biology
  • 1963
TLDR
The tips of rat sperm tails were slightly frayed by mechanical agitation, thus exposing the fibrils, which were then studied by electron microscopy after negative staining, and it can be inferred that they possessed considerable mechanical strength. Expand
THE INTERACTION OF MYOSIN AND ADENOSINETRIPHOSPHATE
  • S. Shen
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1947
TLDR
It is established that myosin can no longer be regarded as an inert protein serving merely as the building blocks of the muscle fibril, but is, in all probability, a functional basis for the muscular activity. Expand
Microfilaments in Cellular and Developmental Processes
TLDR
The overall conclusion is that a broad spectrum of cellular and developmental processes are caused by contractile apparatuses that have at least the common feature of being sensitive to cytochalasin. Expand
Cell Motility by Labile Association of Molecules
TLDR
This article summarizes the current views on the dynamic structure of the mitotic spindle and its relation to mitotic chromosome movements based on measurements of birefringence of spindle fibers in living cells, normally developing or experimentally modified by various physical and chemical agents. Expand
Cytoplasmic contractile proteins
  • T. Pollard
  • Biology, Medicine
  • The Journal of cell biology
  • 1981
TLDR
Some of the important events in the growth of cytoplasmic contractile protein research are highlighted and some future trends are forecast to be forecast. Expand
Microtubules: a brief historical perspective.
  • W. Brinkley
  • Biology, Medicine
  • Journal of structural biology
  • 1997
TLDR
Research on the morphology and molecular structure of microtubules spans 3 decades and is now entering an exciting new "biophysical" era, as described in this issue. Expand
...
1
2
3
4
5
...