Recurring local sequence motifs in proteins.

  title={Recurring local sequence motifs in proteins.},
  author={Karen F Han and David Baker},
  journal={Journal of molecular biology},
  volume={251 1},
We describe a completely automated approach to identifying local sequence motifs that transcend protein family boundaries. Cluster analysis is used to identify recurring patterns of variation at single positions and in short segments of contiguous positions in multiple sequence alignments for a non-redundant set of protein families. Parallel experiments on simulated data sets constructed with the overall residue frequencies of proteins but not the inter-residue correlations show that naturally… CONTINUE READING

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