Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy.

@article{Stoellberger2017RecurrentVT,
  title={Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy.},
  author={Claudia Stoellberger and Josef Finsterer},
  journal={Neurologia i neurochirurgia polska},
  year={2017},
  volume={51 2},
  pages={194-196}
}
BACKGROUND The direct oral anticoagulant (DOAC) rivaroxaban, an oral Factor Xa inhibitor, is increasingly used as an alternative to vitamin-K-antagonists (VKAs). Absorption and elimination of DOACs are dependent on the permeability glycoprotein (P-gp) efflux transporter protein system, and DOACs are substrates of the hepatic cytochrome P 450 3A4 (CYP3A4) enzymes. Therefore, drug-interactions may occur when DOACs are administered with drugs affecting the activity of P-gp or CYP3A4 systems… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS