Recurrent turnover of senescent cells during regeneration of a complex structure

  title={Recurrent turnover of senescent cells during regeneration of a complex structure},
  author={Maximina H Yun and Hongorzul Davaapil and Jeremy P. Brockes},
Cellular senescence has been recently linked to the promotion of age-related pathologies, including a decline in regenerative capacity. While such capacity deteriorates with age in mammals, it remains intact in species such as salamanders, which have an extensive repertoire of regeneration and can undergo multiple episodes through their lifespan. Here we show that, surprisingly, there is a significant induction of cellular senescence during salamander limb regeneration, but that rapid and… CONTINUE READING
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