Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphoma.

  title={Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphoma.},
  author={Stephen J. Salipante and Andrew C Adey and Anju Sarah Thomas and Choli Lee and Yajuan J Liu and Akash Kumar and Alexandra P. Lewis and David Wu and Jonathan R. Fromm and Jay Shendure},
  journal={Genes, chromosomes & cancer},
  volume={55 3},
Investigation of the genetic lesions underlying classical Hodgkin lymphoma (CHL) has been challenging due to the rarity of Hodgkin and Reed-Sternberg (HRS) cells, the pathognomonic neoplastic cells of CHL. In an effort to catalog more comprehensively recurrent copy number alterations occurring during oncogenesis, we investigated somatic alterations involved in CHL using whole-genome sequencing-mediated copy number analysis of purified HRS cells. We performed low-coverage sequencing of small… CONTINUE READING
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