Recurrent severe infantile cortical hyperostosis (Caffey disease) in siblings.

  title={Recurrent severe infantile cortical hyperostosis (Caffey disease) in siblings.},
  author={B M Drinkwater and Jude P Crino and Jes{\'u}s Caja Garc{\'i}a and James Ogburn and Jacqueline Tauber Hecht},
  journal={Prenatal diagnosis},
  volume={17 8},
Infantile cortical hyperostosis (ICH), Caffey disease, is a multifocal, inflammatory skeletal process with classic onset before the fifth month of life and resolution by the age of 3 years. A severe phenotype with early prenatal onset has also been described. Inheritance is generally accepted a autosomal dominant with variable expression and penetrance. However, occurrence in siblings with no family history has been reported, raising the possibility of heterogeneity and the existence of a… CONTINUE READING

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